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Although endogenous H 2 S level was not measured following administration of ALA in ADPKD patients in the above clinical study, it is possible that the beneficial effect of ALA in this group of patients could be due to increased expression of H 2 S-producing enzymes and endogenous H 2 S production by ALA along with the potent antioxidant, anti-inflammatory and other therapeutic properties of H 2 S